Can I read Digest It All: the Lysosomal Turnover of Cytoplasmic Aggregates on EtoBox?

Digest It All: the Lysosomal Turnover of Cytoplasmic Aggregates by Mario Mauthe; Harm H. Kampinga; Mark S. Hipp; Fulvio Reggiori is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Digest It All: the Lysosomal Turnover of Cytoplasmic Aggregates about?

Aggrephagy describes the selective lysosomal transport and turnover of cytoplasmic protein aggregates by macro-autophagy. In this process, protein aggregates and conglomerates are polyubiquitinated and then sequestered by autophagosomes. Soluble selective autophagy receptors (SARs) are central to aggrephagy and physically bind to both ubiquitin and the autophagy machinery, thus linking the cargo to the forming autophagosomal membrane. Because the accumulation of protein aggregates is associated with cytotoxicity in several diseases, a better molecular understanding of aggrephagy might provide a conceptual framework to develop therapeutic strategies aimed at delaying the onset of these pathologies by preventing the buildup of potentially toxic aggregates. We review recent advances in our knowledge about the mechanism of aggrephagy.

Who reads Digest It All: the Lysosomal Turnover of Cytoplasmic Aggregates?

Author

Mario Mauthe; Harm H. Kampinga; Mark S. Hipp; Fulvio Reggiori

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)