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Persistent epileptiform activity induced by low Mg^2+^ in intact immature brain structures by P. P. Quilichini; D. Diabira; C. Chiron; Y. Ben-Ari; H. Gozlan is a Neuroscience article available to read on EtoBox.

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## Abstract We have determined the properties of seizures induced __in vitro__ during the first postnatal days using intact rat cortico‐hippocampal formations (CHFs) and extracellular recordings. Two main patterns of activity were generated by nominally Mg^2+^‐free ACSF in hippocampal and cortical regions: ictal‐like events (ILEs) and late recurrent interictal discharges (LRDs). They were elicited at distinct developmental periods and displayed different pharmacological properties. ILEs were first observed in P1 CHFs 52 ± 7 min after application of low‐Mg^2+^ ACSF (frequency 1.5 ± 0.3 h^‐1^, duration 86 ± 3 s). There is a progressive age‐dependent maturation of ILEs characterized by a decrease in their onset and an increase in their frequency and duration. ILEs were abolished by d‐APV and Mg^2+^ ions. From P7, ILEs were followed by LRDs that appeared 89 ± 8 min after application of low‐Mg^2+^ ACSF (frequency ≈ 1 Hz, duration 0.66 s, amplitude 0.31 ± 0.03 mV). LRDs were no longer sensitive to d‐APV or Mg^2+^ ions and persisted for at least 24 h in low‐Mg^2+^ or in normal ACSF. ILEs and LRDs were synchronized in limbic and cortical regions with 10–40 ms latency between the onsets of

Who reads Persistent epileptiform activity induced by low Mg^2+^ in intact immature brain structures?

Author

P. P. Quilichini; D. Diabira; C. Chiron; Y. Ben-Ari; H. Gozlan

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)