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Urinary albumin-to-creatinine ratio within normal range and all-cause or cardiovascular mortality among U.S. adults enrolled in the NHANES during 1999–2015 by Kosuke Inoue; Elani Streja; Tetsuro Tsujimoto; Hiroki Kobayashi is a Medicine article available to read on EtoBox.

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## Purpose: Urinary albumin-to-creatinine ratio (uacr) is one of the important diagnostic markers of chronic kidney disease. we aimed to investigate the association between uacr within normal range and cardiovascular or all-cause mortality. ## Methods: This study included a nationally representative sample of 31,413 u.s. adults aged greater than or equal to 20 years enrolled in the national health and nutrition examination survey 1999-2014. mortality was ascertained through 2015. we used multivariable cox proportional models to investigate the association of uacr with all-cause and cardiovascular mortality. stratum-specific analyses were conducted by age, sex, race, education status, and comorbidities (e.g., hypertension, diabetes, cardiovascular disease, and chronic kidney disease). ## Results: Over a median follow-up of 7.6 years, 2854 all-cause deaths and 454 cardiovascular deaths were identified. higher uacr (per 10 mg/g) was associated with increased risk of all-cause mortality (adjusted hazard ratio = 1.29, 95% confidence interval = 1.22-1.37) and cardiovascular mortality (adjusted hazard ratio = 1.34, 95% confidence interval = 1.17-1.55). the association was larger among wom

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Author

Kosuke Inoue; Elani Streja; Tetsuro Tsujimoto; Hiroki Kobayashi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1047-2797)

Published

2020

Language

EN

Field

Medicine (Health Sciences)