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Hepatoprotective Effects of Antrodia cinnamomea : The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury by Yange Liu; Juan Wang; Lanzhou Li; Wenji Hu; Yidi Qu; Yipei Ding; Lina Meng; Lirong Teng; Di Wang is a Medicine article available to read on EtoBox.
What is Hepatoprotective Effects of Antrodia cinnamomea : The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury about?
In the present study, the components of __A. cinnamomea__ (AC) mycelia were systematically analyzed. Subsequently, its hepatoprotective effects and the underlying mechanisms were explored using a mouse model of acute alcohol-induced liver injury. AC contained 25 types of fatty acid, 16 types of amino acid, 3 types of nucleotide, and 8 types of mineral. The hepatoprotective effects were observed after 2 weeks of AC treatment at doses of 75 mg/kg, 225 mg/kg, and 675 mg/kg in the mouse model. These effects were indicated by the changes in the levels of aspartate aminotransferase, alanine aminotransferase, several oxidation-related factors, and inflammatory cytokines in serum and/or liver samples. AC reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis in liver detecting via histological and TUNEL assay. In addition, AC reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-__κ__B (NF-__κ__B) in the liver samples. Collectively, AC-mediated hepatoprotective effects in a mouse model of acute alcohol-induced liver injury are the result of reduction in o
Who reads Hepatoprotective Effects of Antrodia cinnamomea : The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol-Induced Acute Liver Injury?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Yange Liu; Juan Wang; Lanzhou Li; Wenji Hu; Yidi Qu; Yipei Ding; Lina Meng; Lirong Teng; Di Wang
- Publisher
- Hindawi Limited
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)