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Can I read EVI1 expression in acute myeloid leukaemia on EtoBox?
EVI1 expression in acute myeloid leukaemia by S. E. Langabeer; J. R. Rogers; G. Harrison; K. Wheatley; H. Walker; B. J. Bain; A. K. Burnett; A. H. Goldstone; D. C. Linch; D. Grimwade; On Behalf Of The Mrc Adult Leukaemia Working Party is a Medicine article available to read on EtoBox.
What is EVI1 expression in acute myeloid leukaemia about?
Acute myeloid leukaemia (AML) with 3q26 cytogenetic abnormalities is associated with overexpression of __EVI1__, dysmegakaryopoiesis and poor prognosis. Screening for __EVI1__ transcripts was performed in 336 cases of AML, including 139 patients with acute promyelocytic leukaemia (APL). Expression was detected in 7 out of 10 cases with and 23 out of 326 without 3q26 abnormalities including one APL case. Among cases lacking 3q abnormalities, detection of __EVI1__ transcripts was neither associated with characteristic dysmegakaryopoietic features, nor predictive of a poor outcome, indicating that screening will probably not assist in treatment stratification. This study nevertheless demonstrates that deregulation of __EVI1__, although rare in APL, is a relatively frequent event in AML.
Who reads EVI1 expression in acute myeloid leukaemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S. E. Langabeer; J. R. Rogers; G. Harrison; K. Wheatley; H. Walker; B. J. Bain; A. K. Burnett; A. H. Goldstone; D. C. Linch; D. Grimwade; On Behalf Of The Mrc Adult Leukaemia Working Party
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)