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Relation of Bone Mineral Density with Clinical and Laboratory Parameters in Pre‐pubertal Children with Cystic Fibrosis by Nazan Cobanoglu; Halil Atasoy; Ugur Ozcelik; Ebru Yalcin; Deniz Dogru; Nural Kiper; Ayhan Gocmen is a Medicine article available to read on EtoBox.
What is Relation of Bone Mineral Density with Clinical and Laboratory Parameters in Pre‐pubertal Children with Cystic Fibrosis about?
## Abstract To study bone mineral density (BMD) of pre‐pubertal cystic fibrosis (CF) children, and its relation with clinical and laboratory parameters, we enrolled 16 CF (8 girls) (4–8 years), and 16 control children (8 girls) (4–8 years). After anthropometric measurements, BMD, serum calcium, phosphorus, total alkaline phosphatase (ALP), 25‐hydroxy vitamin D (25‐OHD), parathyroid hormone, osteocalcin, tumor necrosis factor (TNF)‐α, soluble TNF‐α receptor 2 (sTNFR2), and soluble IL‐2 receptor (sIL‐2R) levels, and urinary calcium and hydroxyproline excretions were assessed. Disease severity of CF patients was determined with Shwachman–Kulczycki clinical and Brasfield radiological scoring systems. The mean Shwachman–Kulczycki and Brasfield scores of CF patients were indicating well‐controlled disease. The anthropometric measurements, mean BMD values, and serum calcium, phosphorus and parathyroid hormone levels were within normal range and similar in both groups. Serum osteocalcin levels were lower, and ALP and 25‐OHD levels were higher in CF. Although 24‐hr urinary calcium excretions was higher in CF patients, hydroxyproline excretions were similar in both groups. There was no diffe
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- Author
- Nazan Cobanoglu; Halil Atasoy; Ugur Ozcelik; Ebru Yalcin; Deniz Dogru; Nural Kiper; Ayhan Gocmen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)