Opening book details…
Can I read Rutin-Loaded Silver Nanoparticles With Antithrombotic Function on EtoBox?
Rutin-Loaded Silver Nanoparticles With Antithrombotic Function by Wu, Haitao; Su, Manlin; Jin, Hui; Li, Xinyu; Wang, Puyu; Chen, Jingxiao; Chen, Jinghua is a Engineering article available to read on EtoBox.
What is Rutin-Loaded Silver Nanoparticles With Antithrombotic Function about?
In this paper, we fabricated rutin-loaded silver nanoparticles (Rutin@AgNPs) as the nano-anticoagulant with antithrombotic function. The serum stability, anticoagulation activity, and bleeding risk of Rutin@AgNPs were evaluated. The results showed Rutin@AgNPs had good serum stability, hemocompatibility, and cytocompatibility. The anticoagulation activity of rutin was maintained, and its stability and aqueous solubility were improved. The Rutin@AgNPs could provide a sustained release to prolong the half-life of rutin. The results of the coagulation parameter assay and thrombus formation test in mice model showed that the activated partial thromboplastin time and prothrombin time were prolonged, and Rutin@AgNPs inhibited the thrombosis in the 48 h period. Moreover, the limited bleeding time indicated that the Rutin@AgNPs significantly minimized the hemorrhage risk of rutin. This Rutin@AgNPs is a potential anticoagulant for antithrombotic therapy.
Who reads Rutin-Loaded Silver Nanoparticles With Antithrombotic Function?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Wu, Haitao; Su, Manlin; Jin, Hui; Li, Xinyu; Wang, Puyu; Chen, Jingxiao; Chen, Jinghua
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-4185)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)