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A τ Promoter Region Without Neuronal Specificity by Athena Andreadis; Bridget K. Wagner; Jennifer A. Broderick; Kenneth S. Kosik is a Neuroscience article available to read on EtoBox.

What is A τ Promoter Region Without Neuronal Specificity about?

Abstract: The microtubule‐associated protein τ is produced from a 6‐kb mRNA expressed primarily in neurons. A 2‐kb τ mRNA has also been characterized, which produces a τ isoform that localizes to the nucleus, and an 8‐kb mRNA is expressed in the PNS. Mapping and sequencing of the human τ gene start showed that it has an unusually GC‐rich 5′‐untranslated region coded by a single untranslated exon (designated −1). Primer extensions and expression assays indicated that upstream of exon −1 is a promoter that is not neuron specific. This region contains consensus binding sites for transcription factors AP2, Sp1, and GCF.

Who reads A τ Promoter Region Without Neuronal Specificity?

Author

Athena Andreadis; Bridget K. Wagner; Jennifer A. Broderick; Kenneth S. Kosik

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1996

Language

EN

Field

Neuroscience (Life Sciences)