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Can I read Factor X activator from Vipera lebetina venom is synthesized from different genes on EtoBox?
Factor X activator from Vipera lebetina venom is synthesized from different genes by Ene Siigur; Anu Aaspõllu; Katrin Trummal; Külli Tõnismägi; Indrek Tammiste; Nisse Kalkkinen; Jüri Siigur is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Factor X activator from Vipera lebetina venom is synthesized from different genes about?
Vipera lebetina venom contains specific coagulant Factor X activator (VLFXA) that cleaves the Arg 52 -Ile 53 bond in the heavy chain of human factor X. VLFXA is a glycoprotein that is composed of a heavy chain (HC) and two light chains (LC) linked by disulfide bonds. The complete amino acid sequences of the three chains of the factor X activator from V. lebetina snake venom are deduced from the nucleotide sequences of cDNAs encoding these chains. The full-length cDNA (2347 bp) sequence of the HC encodes an open reading frame (ORF) of 612 amino acids that includes signal peptide, propeptide and mature metalloproteinase with disintegrin-like and cysteine-rich domains. The light chain LC1 contains 123 and LC2 135 amino acid residues. Both light chains belong to the class of C-type lectin-like proteins. The Ntermini of VLFXA chains and inner sequences of peptide fragments detected by liquid chromatography-electrospray ionization tandem mass spectrometry (LC MS/MS) from protein sequence are 100% identical to the sequences deduced from the cDNA. The molecular masses of tryptic fragments of VLFXA chains analyzed by matrix-assisted laser desorption ionization time of flight mass spectromet
Who reads Factor X activator from Vipera lebetina venom is synthesized from different genes?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ene Siigur; Anu Aaspõllu; Katrin Trummal; Külli Tõnismägi; Indrek Tammiste; Nisse Kalkkinen; Jüri Siigur
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1570-9639)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)