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Potential Mechanisms for Amelioration of Type 2 Diabetes Following Bariatric Surgery by Dohm, G. Lynis;Reed, Melissa Anne;East Carolina University. Department of Department of Kinesiology is a nonfiction available to read on EtoBox.

What is Potential Mechanisms for Amelioration of Type 2 Diabetes Following Bariatric Surgery about?

Severe obesity and Type 2 Diabetes (T2DM) are worldwide health concerns reaching epidemic proportions. Roux-en-Y gastric bypass (RYGB) has been shown to elicit a rapid and durable improvement and/or remission of T2DM in as little as one week following surgery in approximately 80% of patients, however the exact mechanism(s) responsible for this remission remain unknown. It was the central hypothesis of this project that T2DM is rapidly ameliorated following RYGB in part by increasing skeletal muscle insulin sensitivity. Study One: To test this hypothesis we examined insulin sensitivity and insulin secretion in severely obese non-diabetic and T2DM women prior to RYGB and 1 week and 3 months post-RYGB using an insulin-modified intravenous glucose tolerance test (IVGTT) with Minimal Model analysis. Insulin sensitivity and insulin secretion were measured in lean women as a control group. One week after RYGB, insulin sensitivity in T2DM doubled compared to pre-RYGB but was still impaired (S1 approximately 50% of lean controls) and insulin secretion was improved but not restored (AIRg approximately 50% of lean controls). Remarkably, fasting insulin decreased one week post-RYGB and was no

Who reads Potential Mechanisms for Amelioration of Type 2 Diabetes Following Bariatric Surgery?

Author

Dohm, G. Lynis;Reed, Melissa Anne;East Carolina University. Department of Department of Kinesiology

Publisher

East Carolina University

Published

2011

Language

EN

Category

nonfiction