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Synthesis Biological Activity and Molecular Dockin by ifratjahanerin13593 is a document available to read on EtoBox.
The study synthesizes 25 new tricyclic compounds as α-glucosidase inhibitors, demonstrating that compounds 6h and 6d exhibit stronger inhibitory activity than the established drug acarbose, with compound 6h showing an IC50 of 104.07 µM. Molecular docking studies indicate that compound 6h forms a stable complex with α-glucosidase, enhancing its inhibitory effects. This research highlights the potential of these new compounds as effective antidiabetic agents with fewer gastrointestinal side effects compared t
- Author
- ifratjahanerin13593
- Language
- EN