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Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation by Na Zhao; Qiu-Gu Chen; Xiu Chen; Xue-Ting Liu; Fan Geng; Meng-Meng Zhu; Fu-Ling Yan; Zhi-Jun Zhang; Qing-Guo Ren is a Neuroscience article available to read on EtoBox.
What is Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation about?
Growing evidence suggests the involvement of the microbiota-gut-brain axis in cognitive impairment induced by sleep deprivation (SD), however how the microbiota-gut-brain axis work remains elusive. Here, we discovered that chronic SD induced intestinal dysbiosis, activated NLRP3 inflammasome in the colon and brain, destructed intestinal/blood–brain barrier, and impaired cognitive function in mice. Transplantation of “SD microbiota” could almost mimic the pathological and behavioral changes caused by chronic SD. Furthermore, all the behavioral and pathological abnormalities were practically reversed in chronic sleep-deprived NLRP3-/- mice. Regional knockdown NLRP3 expression in the gut and hippocampus, respectively. We observed that down-regulation of NLRP3 in the hippocampus inhibited neuroinflammation, and ameliorated synaptic dysfunction and cognitive impairment induced by chronic SD. More intriguingly, the down-regulation of NLRP3 in the gut protected the intestinal barrier, attenuated the levels of peripheral inflammatory factors, down-regulated the expression of NLRP3 in the brain, and improved cognitive function in chronic SD mice. Our results identified gut microbiota as a d
Who reads Intestinal dysbiosis mediates cognitive impairment via the intestine and brain NLRP3 inflammasome activation in chronic sleep deprivation?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Na Zhao; Qiu-Gu Chen; Xiu Chen; Xue-Ting Liu; Fan Geng; Meng-Meng Zhu; Fu-Ling Yan; Zhi-Jun Zhang; Qing-Guo Ren
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)