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A Fibre Tracking Algorithm for Volumetric Microstructural Data - Application to Tendons by Helena Raymond-Hayling; Yinhui Lu; Karl E. Kadler; Tom Shearer is a Engineering article available to read on EtoBox.

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Tendons are crucial connective tissues made almost entirely of bundles of long, near-parallel collagen fibrils, and are vitally important to skeletal stability and mechanical function. Tendon structure is typically quantified in 2D, whereas, in this work, we have used serial block face-scanning electron microscopy to image tendons in 3D. We present a custom fibre tracking algorithm (FTA), with which we have characterised the 3D microstructure of tendon. Currently available tools for fibre tracing were unsuitable for tracking large numbers of fibrils and handling imaging artefacts associated with EM. We have tracked fibrils through a representative tendon volume and measured their relative length, diameter, orientation, chirality, tortuosity and volume fraction, which are just some of the measurements it is possible to make with the FTA depending on the research question. This algorithm has been developed in a general way and can be applied to a range of biological research questions relating to tendon structure-function relationships, on topics such as ageing, disease, development and injury. The FTA is also applicable to other fibrous biological materials, as well as engineered ma

Who reads A Fibre Tracking Algorithm for Volumetric Microstructural Data - Application to Tendons?

Author

Helena Raymond-Hayling; Yinhui Lu; Karl E. Kadler; Tom Shearer

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Engineering (Physical Sciences)