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The effects of Aronia berry (poly)phenol supplementation on arterial function and the gut microbiome in middle aged men and women: Results from a randomized controlled trial by Melanie Le Sayec; Yifan Xu; Manolo Laiola; Fabiola Alvarez Gallego; Daphne Katsikioti; Chandler Durbidge; Uku Kivisild; Sarah Armes; Manon Lecomte; Pascale Fança-Berthon; Emilie Fromentin; Florian Plaza Oñate; J Kennedy Cruickshank; Ana Rodriguez-Mateos is a Medicine article available to read on EtoBox.

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## Background and aims: Berry (poly)phenol consumption has been associated with cardioprotective benefits, however little is known on the role the gut microbiome may play on such health benefits. our objective was to investigate the effects of aronia berry (poly)phenol consumption on cardiometabolic health and gut microbiome richness and composition in prehypertensive middle-aged men and women. ## Methods: A total of 102 prehypertensive participants were included in a parallel 12-week randomized double-blind placebo-controlled trial. volunteers were randomly allocated to daily consume an encapsulated (poly)phenol-rich aronia berry extract (aronia, n = 51) or a matched maltodextrin placebo (control, n = 51). blood pressure (bp) and arterial function (office and 24 h), endothelial function (measured as flow-mediated dilation), serum biochemistry (including blood lipids), plasma and urine (poly)phenol metabolites as well as gut microbiome composition through shotgun metagenomic sequencing were monitored over the study period. relationships between vascular outcomes, (poly)phenol metabolites and gut microbiome were investigated using an integrated multi-levels approach. ## Results: A s

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Author

Melanie Le Sayec; Yifan Xu; Manolo Laiola; Fabiola Alvarez Gallego; Daphne Katsikioti; Chandler Durbidge; Uku Kivisild; Sarah Armes; Manon Lecomte; Pascale Fança-Berthon; Emilie Fromentin; Florian Plaza Oñate; J Kennedy Cruickshank; Ana Rodriguez-Mateos

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)