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The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection by Keying Yu; Yu-Yao Guo; Tianzi Liuyu; Peng Wang; Zhi-Dong Zhang; Dandan Lin; Bo Zhong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection about?
Dysfunction of the intestinal epithelial barrier causes microbial invasion that would lead to inflammation in the gut. Antimicrobial peptides (AMPs) are essential components of the intestinal epithelial barrier, while the regulatory mechanisms of AMPs expression are not fully characterized. Here, we report that the ovarian tumor family deubiquitinase 4 (OTUD4) in Paneth cells restricts the expression of AMPs and thereby promotes experimental colitis and bacterial infection. OTUD4 is upregulated in the inflamed mucosa of ulcerative colitis patients and in the colon of mice treated with dextran sulfate sodium salt (DSS). Knockout of OTUD4 promotes the expression of AMPs in intestinal organoids after stimulation with lipopolysaccharide (LPS) or peptidoglycan (PGN) and in the intestinal epithelial cells (IECs) of mice after DSS treatment or __Salmonella__ typhimurium (__S__.t.) infection. Consistently, __Vil__-Cre;__Otud4__^fl/fl^ mice and __Def__-Cre;__Otud4__^fl/fl^ mice exhibit hyper-resistance to DSS-induced colitis and __S__.t. infection compared to __Otud4__^fl/fl^ mice. Mechanistically, knockout of OTUD4 results in hyper K63-linked ubiquitination of MyD88 and increases the activ
Who reads The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Keying Yu; Yu-Yao Guo; Tianzi Liuyu; Peng Wang; Zhi-Dong Zhang; Dandan Lin; Bo Zhong
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)