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Amikacin Alters Auditory Brainstem Conduction Time in Newborns by A. Poblano; A. Belmont; J. Sosa; J. Ibarra; A. M. Vargas; G. Limón; C. Martínez is a Medicine article available to read on EtoBox.

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The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range levels in newborns as index of drug toxicity in brainstem auditory centers in neonatally exposed infants. We performed a cross-sectional study to compare BAEP from 35 infants under amikacin administration and 24 control infants; both examinations were blinded to investigators. Bivariate and partial correlations were calculated between amikacin and BAEP measurements in treated infants. Amikacin determinations were within therapeutic levels. No clinical alterations in BAEP were found and no differences between amikacin-treated and control infants were found. Significant positive Pearson correlation between latency of I-III interwaves interval and amikacin Cmin serum levels was found and was present when calculations were controlled by partial correlations for gestational age at birth and Apgar score at 5 min. The findings suggest that increased amikacin levels in newborns are related to increased latencies in I-III interwave interval in infants, which may be an early index of br

Who reads Amikacin Alters Auditory Brainstem Conduction Time in Newborns?

Author

A. Poblano; A. Belmont; J. Sosa; J. Ibarra; A. M. Vargas; G. Limón; C. Martínez

Publisher

Walter de Gruyter GmbH

Published

2003

Language

EN

Field

Medicine (Health Sciences)