Opening book details…
Can I read Aminoguanidine Treatment Ameliorates Inflammatory Responses and Memory Impairment Induced by Amyloid-beta 25–35 Injection in Rats on EtoBox?
Aminoguanidine Treatment Ameliorates Inflammatory Responses and Memory Impairment Induced by Amyloid-beta 25–35 Injection in Rats by Alfonso Díaz; Karla Rojas; Blanca Espinosa; Raúl Chávez; Edgar Zenteno; Daniel Limón; Jorge Guevara is a Neuroscience article available to read on EtoBox.
What is Aminoguanidine Treatment Ameliorates Inflammatory Responses and Memory Impairment Induced by Amyloid-beta 25–35 Injection in Rats about?
Alzheimer disease (AD) is a neurodegenerative disorder caused by accumulation of the amyloid-beta peptide (Aβ) in neuritic plaques. Its neurotoxic mechanisms are associated with inflammatory responses and nitrosative stress generation that promote expression of inducible nitric oxide synthase (iNOS) and increased nitric oxide causing neuronal death and memory impairment. Studies suggest that treatment with anti-inflammatory and anti-oxidant agents decreases the risk of developing AD. Aminoguanidine (AG) is an iNOS inhibitor with anti-inflammatory and anti-oxidant effects. In this study, we evaluated the effects of systemic administration of AG (100mg/kg/day for 4days) on spatial memory and inflammatory responses induced by an injection of Aβ25–35 [100μM] into the temporal cortex (TCx) of rats. A significant improvement of spatial memory was evident in the Aβ25–35-treated group at day 30 post-injection subjected to AG treatment; this effect was correlated with decreases in reactive gliosis, IL-1β, TNF-α, and nitrite levels, as well as a reduction in neurodegeneration in the TCx and hippocampus (Hp). These results suggest that AG treatment inhibited glia activation and cytokine relea
Who reads Aminoguanidine Treatment Ameliorates Inflammatory Responses and Memory Impairment Induced by Amyloid-beta 25–35 Injection in Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Alfonso Díaz; Karla Rojas; Blanca Espinosa; Raúl Chávez; Edgar Zenteno; Daniel Limón; Jorge Guevara
- Publisher
- Elsevier BV
- Published
- 2014
- Language
- EN
- Field
- Neuroscience (Life Sciences)