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Anti-inflammatory Effect of the Monoterpene Myrtenol Is Dependent on the Direct Modulation of Neutrophil Migration and Oxidative Stress by Bruno S. Gomes; Benedito P.S. Neto; Everton M. Lopes; Francisco V.M. Cunha; Alyne R. Araújo; Carlos W.S. Wanderley; Deysi V.T. Wong; Roberto César P.L. Júnior; Ronaldo A. Ribeiro; Damião P. Sousa; Jand Venes R Medeiros; Rita C.M. Oliveira; Francisco A. Oliveira is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Anti-inflammatory Effect of the Monoterpene Myrtenol Is Dependent on the Direct Modulation of Neutrophil Migration and Oxidative Stress about?
Myrtenol is a bicyclic monoterpene with anti-inflammatory properties. However, the mechanisms involved are partially unknown. Here, we investigated the effect of myrtenol during experimental chronic arthritis and the possible modulating activity of oxidative stress and neutrophil migration. Complete Freund's Adjuvant (CFA)-sensitized rats were treated with vehicle (1 mL/kg, po), myrtenol (12.5, 25 or 50 mg/kg, po), indomethacin (10 mg/kg, po) or dexamethasone (0.4 mg/kg) followed by intra-articular injection of CFA (0.5 mg/mL, 50 μL per joint). Then, paw edema and articular incapacitation (paw elevation time) were evaluated for 14 days. On the last day, a blood concentration superoxide dismutase (SOD) and nitrite was determined. In another experimental setting, human neutrophils were incubated with vehicle (sterile saline, 1 mL) or myrtenol (10-100 ng/mL) and the in vitro chemotaxis to N-formylmethionine-leucyl-phenylalanine (fMLP) (10 M/well) was evaluated. In addition, antiinflammatory effect of myrtenol was investigated in carrageenan-induced peritonitis. We found that CFA induced a prominent paw swelling and incapacitation of the joint, which were significantly prevented by myr
Who reads Anti-inflammatory Effect of the Monoterpene Myrtenol Is Dependent on the Direct Modulation of Neutrophil Migration and Oxidative Stress?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bruno S. Gomes; Benedito P.S. Neto; Everton M. Lopes; Francisco V.M. Cunha; Alyne R. Araújo; Carlos W.S. Wanderley; Deysi V.T. Wong; Roberto César P.L. Júnior; Ronaldo A. Ribeiro; Damião P. Sousa; Jand Venes R Medeiros; Rita C.M. Oliveira; Francisco A. Oliveira
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-2797)
- Published
- 2017
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)