About this Medicine article
Localized ^1^H NMR spectra of glutamate in the human brain by D. L. Rothman; C. C. Hanstock; O. A. C. Petroff; E. J. Novotny; J. W. Prichard; R. G. Shulman is a Medicine article available to read on EtoBox.
## Abstract Localized ^1^H NMR spectra at TE = 12 ms were obtained from cerebralcortex of human subjects using ISIS with surface suppression. The 2.29‐ppm resonance was assigned to C4 glutamate with contributions from C4 glutamine and GABA using __in vivo__ spectral editing and comparison of chemical shift with pure compounds. The measured intensity ratio between the 2.29 resonance and the creatine resonance at 3.03 ppm was in good agreement with the ratio predicted from previously reported measurements of glutamate. glutamine, and GABA concentrations in biopsied human brain tissue.
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- Author
- D. L. Rothman; C. C. Hanstock; O. A. C. Petroff; E. J. Novotny; J. W. Prichard; R. G. Shulman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 1992
- Language
- EN
- Field
- Medicine (Health Sciences)