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Endoglin expression on human microvascular endothelial cells: Association with betaglycan and formation of higher order complexes with TGF‐β signalling receptors by S. H. Wong; L. Hamel; S. Chevalier; A. Philip is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Endoglin expression on human microvascular endothelial cells: Association with betaglycan and formation of higher order complexes with TGF‐β signalling receptors about?

Transforming growth factor‐β (TGF‐β) plays an important role in angiogenesis and vascular function. Endoglin, a transmembrane TGF‐β binding protein, is highly expressed on vascular endothelial cells and is the target gene for the hereditary haemorrhagic telangiectasia type I (HHT1), a dominantly inherited vascular disorder. The specific function of endoglin responsible for HHT1 is believed to involve alterations in TGF‐β responses. The initial interactions on the cell surface between endoglin and TGF‐β receptors may be an important mechanism by which endoglin modulates TGF‐β signalling, and thereby responses. Here it is shown that on human microvascular endothelial cells, endoglin is co‐expressed and is associated with betaglycan, a TGF‐β accessory receptor with which endoglin shares limited amino acid homology. This complex formation may occur in either a ligand‐dependent or a ligand‐independent manner. In addition, the occurrence of three higher order complexes containing endoglin, type II and/or type I TGF‐β receptors, on these cells is demonstrated. Our findings suggest that endoglin may modify TGF‐β signalling by interacting with both betaglycan and the TGF‐β signalling recept

Who reads Endoglin expression on human microvascular endothelial cells: Association with betaglycan and formation of higher order complexes with TGF‐β signalling receptors?

Author

S. H. Wong; L. Hamel; S. Chevalier; A. Philip

Publisher

John Wiley and Sons; Springer; Wiley (Blackwell Publishing); Springer-Verlag; Blackwell Publishing Inc.; Springer Verlag; Wiley; Springer Science and Business Media LLC (ISSN 1432-1327)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)