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This article investigates the neural mechanisms behind fasting-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis, highlighting the role of agouti-related peptide (AgRP)-expressing neurons in this process. The study demonstrates that these neurons trigger HPA axis activation through presynaptic inhibition of GABAergic afferents, leading to increased glucocorticoid hormone release, which is crucial for maintaining energy balance during fasting. Importantly, this activation occurs independent

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kasslervera513

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EN