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Dispensing Patterns and Pregnancy Outcomes for Women Dispensed Selective Serotonin Reuptake Inhibitors in Pregnancy by Lyn Colvin; Linda Slack-Smith; Fiona J. Stanley; Carol Bower is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND The safety of selective serotonin reuptake inhibitors (SSRIs) during pregnancy remains uncertain. The purpose of this study was to investigate dispensing patterns and pregnancy outcomes for women dispensed an SSRI in pregnancy. ## METHODS Using data linkage of population‐based health datasets from Western Australia and a national pharmaceutical claims dataset, our study included 123,405 pregnancies from 2002 to 2005. There were 3764 children born to 3703 women who were dispensed an SSRI during their pregnancy. ## RESULTS A total of 42.3% of the women were dispensed an SSRI in each trimester, and 97.6% of the women used the same SSRI throughout the first trimester without switching. The women who were dispensed an SSRI were more likely to give birth prematurely (adjusted odds ratio [aOR], 1.4; 95% confidence interval [CI], 1.2–1.7), to have smoked during the pregnancy (OR, 1.9; 95% CI, 1.8–2.1), and parity >1 (OR, 1.7; 95% CI, 1.5–1.8). The singletons were found to have a lower birth weight than expected when other factors were taken into account (OR, 1.2; 95% CI, 1.1–1.3). There was an increased risk of major cardiovascular defects (OR, 1.6; 95% CI, 1.1–2.

Who reads Dispensing Patterns and Pregnancy Outcomes for Women Dispensed Selective Serotonin Reuptake Inhibitors in Pregnancy?

Author

Lyn Colvin; Linda Slack-Smith; Fiona J. Stanley; Carol Bower

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-0752)

Published

2011

Language

EN

Field

Medicine (Health Sciences)