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Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin by Pasha A. Davoudian; Ling-Xiao Shao; Alex C. Kwan is a Neuroscience article available to read on EtoBox.

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Psilocybin is a psychedelic with therapeutic potential. While there is growing evidence that psilocybin exerts its beneficial effects through enhancing neural plasticity, the exact brain regions involved are not completely understood. Determining the impact of psilocybin on plasticity-related gene expression throughout the brain can broaden our understanding of the neural circuits involved in psychedelic-evoked neural plasticity. In this study, whole-brain serial two-photon microscopy and light sheet microscopy were employed to map the expression of the immediate early gene, c-Fos, in male and female mice. The druginduced c-Fos expression following psilocybin administration was compared to that of subanesthetic ketamine and saline control. Psilocybin and ketamine produced acutely comparable elevations in c-Fos expression in numerous brain regions, including anterior cingulate cortex, locus coeruleus, primary visual cortex, central and basolateral amygdala, medial and lateral habenula, and claustrum. Select regions exhibited drug-preferential differences, such as dorsal raphe and insular cortex for psilocybin and the CA1 subfield of hippocampus for ketamine. To gain insights into th

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Author

Pasha A. Davoudian; Ling-Xiao Shao; Alex C. Kwan

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)