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Clinical Efficacy of SARS-CoV-2 Vaccination in Hemodialysis Patients by Torres, Rubén (author);Toro, Luis (author);Sanhueza, María Eugenia (author);Lorca, Eduardo (author);Ortiz, Mireya (author);Pefaur, Jacqueline (author);Clavero, Rene (author);Machuca, Eduardo (author);Gonzalez, Fernando (author);Herrera, Patricia (author);Mocarquer, Alfredo (author);Frias, Alondra (author);Roessler, Eric (author);Muñoz, Carolina (author);Nuñez, Miguel (author);Aravena, Cesar (author);Quintana, Enrique (author);Lemus, Juan (author);Lillo, Mario (author);Reynolds, Enrique (author);Morales, Alvaro (author);Pais, Edgard (author);Fiabane, Andrea (author);Parra-Lucares, Alfredo (author);Garrido, Cristian (author);Mendez-Valdes, Gabriel (author);Villa, Eduardo (author);Mansilla, Rodrigo (author);Sotomayor, Germana (author);Gonzalez, Marcela (author);Miranda, Cecilia (author);Briones, Eduardo (author);Gomez, Esteban (author);Mezzano, Sergio (author);Bernales, Waldo (author);Rocca, Ximena (author);Espinoza, Oscar (author);Zuñiga, Eric (author);Aragon, Henry (author);Badilla, Marta (author);Valenzuela, Marcela (author);Escobar, Luis (author);Zamora, Daniela (author);Flores, Ivan (author);Tapia, Beatriz (author);Borquez, Tamara (author);Herrera, Patricio (author) is a Medicine article available to read on EtoBox.

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## Introduction The COVID-19 pandemic is a global public health problem. Patients with end-stage renal disease on hemodialysis are at a higher risk of infection and mortality than the general population. Worldwide, a vaccination campaign has been developed that has been shown to reduce severe infections and deaths in the general population. However, there are currently limited data on the clinical efficacy of vaccinations in the hemodialysis population. ## Methods A national multicenter observational cohort was performed in Chile to evaluate the clinical efficacy of anti-SARS-CoV-2 vaccination in end-stage renal disease patients on chronic hemodialysis from February 2021 to August 2021. In addition, the BNT162b2 (Pfizer-BioNTech) and CoronaVac (Sinovac) vaccines were evaluated. The efficacy of vaccination in preventing SARS-CoV-2 infection, hospitalizations, and deaths associated with COVID-19 was determined. ## Results A total of 12,301 patients were evaluated; 10,615 (86.3%) received a complete vaccination (2 doses), 490 (4.0%) received incomplete vaccination, and 1196 (9.7%) were not vaccinated. During follow-up, 1362 (11.0%) patients developed COVID-19, and 150 died (case fatal

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Author

Torres, Rubén (author);Toro, Luis (author);Sanhueza, María Eugenia (author);Lorca, Eduardo (author);Ortiz, Mireya (author);Pefaur, Jacqueline (author);Clavero, Rene (author);Machuca, Eduardo (author);Gonzalez, Fernando (author);Herrera, Patricia (author);Mocarquer, Alfredo (author);Frias, Alondra (author);Roessler, Eric (author);Muñoz, Carolina (author);Nuñez, Miguel (author);Aravena, Cesar (author);Quintana, Enrique (author);Lemus, Juan (author);Lillo, Mario (author);Reynolds, Enrique (author);Morales, Alvaro (author);Pais, Edgard (author);Fiabane, Andrea (author);Parra-Lucares, Alfredo (author);Garrido, Cristian (author);Mendez-Valdes, Gabriel (author);Villa, Eduardo (author);Mansilla, Rodrigo (author);Sotomayor, Germana (author);Gonzalez, Marcela (author);Miranda, Cecilia (author);Briones, Eduardo (author);Gomez, Esteban (author);Mezzano, Sergio (author);Bernales, Waldo (author);Rocca, Ximena (author);Espinoza, Oscar (author);Zuñiga, Eric (author);Aragon, Henry (author);Badilla, Marta (author);Valenzuela, Marcela (author);Escobar, Luis (author);Zamora, Daniela (author);Flores, Ivan (author);Tapia, Beatriz (author);Borquez, Tamara (author);Herrera, Patricio (author)

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)