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Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays by Sha Liao, Xiaoxi Zhou, Chuanyu Liu, Chang Liu, Shijie Hao, Hongyu Luo is a nonfiction available to read on EtoBox.

What is Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays about?

Single-cell sequencing technologies have advanced our ated microstructures of large sizes and various shapes; and (v) simulunderstanding of cellular heterogeneity and biological taneous determination of the identity and subcellular distribution of complexity. However, existing methods face limitations in each transcript for RNA sequencing.throughput, capture uniformity, cell size flexibility, and By combining DNA nanoball (DNB)–patterned arrays and in situ technical extensibility.-We present Stereo-cell, a spatial RNA capture, we previously created spatial enhanced-resolution omics enhanced-resolution single-cell sequencing platform based on sequencing (Stereo-seq), which enables in situ transcriptome profiling high-density DNA nanoball (DNB)–patterned arrays, which of frozen tissue sections placed onto the chip surface (18, 19). The DNB enables scalable and unbiased cell capture at a wide input chip features densely packed nanoballs (~220 nm in diameter, spaced range and supports high-fidelity transcriptome profiling. 500 nm from center to center) that facilitate encapsulation-free Stereo-cell further allows integration with imaging-based capture of both cells and transcripts.-Th

Who reads Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays?

Author

Sha Liao, Xiaoxi Zhou, Chuanyu Liu, Chang Liu, Shijie Hao, Hongyu Luo

Publisher

x

Published

2025

Language

EN

Category

nonfiction

Subjects

Science, Microbiology, Stem