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Nonribosomal Peptides: from Genes to Products by Dirk Schwarzer; Robert Finking; Mohamed A. Marahiel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nonribosomal Peptides: from Genes to Products about?

The ability to synthesize nonribosomally small bioactive peptides that find application in modern medicine is widely spread among microorganisms. As broad as the spectrum of biological activities is the structural diversity of these peptides, which are mostly cyclic or branched cyclic compounds containing non-proteinogenic amino acids, small heterocyclic rings and other unusual modifications in the peptide backbone. They are synthesized by multimodular enzymes, the so-called nonribosomal peptide synthetases (NRPSs), from simple building blocks. Biochemical and genetic studies have unveiled the key principles of nonribosomal peptide syntheses, as well as the realization of many structural features of these peptides. This review focuses on recent results in NRPS research and highlights how this knowledge can be exploited for biotechnological purposes. In addition, possibilities and limitations for prediction of structural features of uncharacterized NRPSs and approaches for their engineering are discussed. ## Dirk Schwarzer studied chemistry at the Philipps-Universität Marburg (Germany). He joined the group of Mohamed A. Marahiel in 1997 and received his Diploma of chemistry in 1998.

Who reads Nonribosomal Peptides: from Genes to Products?

Author

Dirk Schwarzer; Robert Finking; Mohamed A. Marahiel

Publisher

Royal Society of Chemistry (RSC)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)