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What is Kidney-Targeted Oligonucleotide Delivery about?

This study explores targeted drug delivery using oligonucleotide-peptide conjugates to enhance kidney-specific therapy, particularly for repressing HIF-1α expression in renal tubular cells. A series of kidney-targeting peptides were evaluated for their biodistribution in mice, with the most effective peptide demonstrating a tenfold increase in kidney accumulation while preserving therapeutic activity. The findings suggest that kidney-targeting peptides could significantly improve the efficacy and safety of

Author

dwwhome

Language

EN