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Chemical Synthesis and Hemi-Synthesis of Novel Benzimidazole Derivatives Using Microwave-Assisted Process: Chemical Characterization, Bioactivities and Molecular Docking by Sameut, Asmaâ (author);Zanndouche, Sarah Yasmine (author);Boumaza, Chaimaa (author);Dikes, Chaima (author);Ziani, Borhane Eddine Cherif (author) is a nonfiction available to read on EtoBox.

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Benzimidazole derivatives represent a class of heterocyclic compounds that exhibit a wide range of pharmaceutical properties. The present study aimed to investigate the in-vitro antioxidant and antimicrobial activities of newly synthesized benzimidazole derivatives. Compound 1b (2-(1H-1,3-benzodiazol-2-yl) phenol) was synthesized by reacting o-phenylenediamine (OPA) with chemical salicylaldehyde, while compounds 2b (2-(2-[(1E)-2-phenylethenyl]-1H-1,3-benzodiazole) and 3b (2-[(1E)-2,6-dimethylhepta-1,5-dien-1-yl]-1H-1,3-benzodiazole) were obtained through a hemi-synthesis process of, respectively, the cinnamon (cinnamaldehyde, 90.54%) and lemongrass (cis-citral, 43.9%) essential oils previously characterized by GC/MS. Compounds 4b (2-phenyl-1H-benzimidazole) and 5b (5-(1H-benzimidazol-2-yl)benzene-1,2,3-triol) were synthesized with a click chemistry method by reacting the OPA with benzoic acid and gallic acid directly in ethanol under microwave irradiation (MW) at 400 MHz. The structure/purity of the synthesized compounds was clarified by spectroscopy, ATR-FTIR and NMR 1 H. Compounds 1b-5b were screened for their antioxidant activity by using four complementary in-vitro assays: DPPH

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Author

Sameut, Asmaâ (author);Zanndouche, Sarah Yasmine (author);Boumaza, Chaimaa (author);Dikes, Chaima (author);Ziani, Borhane Eddine Cherif (author)

Publisher

MDPI

Published

2020

Language

EN

Category

nonfiction