About this Biochemistry, Genetics and Molecular Biology article
Five Hub Genes Contributing to the Oncogenesis and Trastuzumab-resistance in Gastric Cancer by Fahai Chen; Yaping Wang; Xinling Zhang; Jianmin Fang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
## Background: Monoclonal antibodies, as the targeted therapeutic strategies, provide huge clinical benefits for tumor patients. however, after undergoing several times treatment, patients developed drug resistance which is a major bottleneck in clinical cancer therapy. in this study, we aimed to explore the potential molecular mechanism of trastuzumab-resistant and cancer progression, and identify valuable diagnosis biomarkers for gastric cancer. ## Materials and methods: Gene expression profiles and rna-sequencing dataset of gastric cancer were acquired from gene expression omnibus (geo) dataset and the cancer genome atlas (tcga) dataset, respectively. the differently expressed genes (degs) were screened by r programing language, and gene set enrichment analysis (gsea), gene ontology (go), and kyoto encyclopedia of genes and genomes (kegg) were adopted separately to analyze the function and pathway of degs. subsequently, search tool for the retrieval of interacting (string) and cytoscape was performed to establish the protein-protein interaction (ppi) network and to screen hub genes. the receiver operating characteristic (roc) curves were used to evaluate the diagnostic values of
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Fahai Chen; Yaping Wang; Xinling Zhang; Jianmin Fang
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)