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In vivo expression of survivin and its splice variant survivin‐2B: Impact on clinical outcome in acute myeloid leukemia by Mandy Wagner; Karin Schmelz; Christian Wuchter; Wolf‐Dieter Ludwig; Bernd Dörken; Ingo Tamm is a Medicine article available to read on EtoBox.
What is In vivo expression of survivin and its splice variant survivin‐2B: Impact on clinical outcome in acute myeloid leukemia about?
## Abstract Survivin, a member of the inhibitor of apoptosis protein family, is expressed in most human cancers, but undetectable in normal differentiated adult tissue __in vivo__. Because of this cancer‐related expression, survivin is a promising target for cancer therapy. To determine the expression and prognostic role of survivin in acute myeloid leukemia (AML), we investigated the mRNA expression pattern of survivin and of the splice variants survivin‐2B and survivin‐ΔEx3 in adult (__n__ = 74) and children (__n__ = 31) with __de novo__ AML using RT‐PCR. Survivin was the predominant transcript variant in AML cells, whereas significantly lower levels of survivin‐2B and survivin‐ΔEx3 were observed (__p__ ≤ 0.0001). Neither expression of survivin nor of any splice variant correlated with maturation stage (FAB subtypes, immunophenotype) or cytogenetic risk groups. For AML cases treated according to AMLCG92 (adult) and AML‐BFM93 (children) protocols, respectively, expression patterns were correlated with clinical data: In adult AML (__n__ = 51), low expression of survivin‐2B correlated with a better overall survival (__p__ = 0.05; mean survival time 19 months __vs.__ 9 months) and a
Who reads In vivo expression of survivin and its splice variant survivin‐2B: Impact on clinical outcome in acute myeloid leukemia?
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- Author
- Mandy Wagner; Karin Schmelz; Christian Wuchter; Wolf‐Dieter Ludwig; Bernd Dörken; Ingo Tamm
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)