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Sperm DNA fragmentation and oxidation are independent of malondialdheyde by Nassira Zribi; Nozha Feki Chakroun; Henda Elleuch; Fatma Ben Abdallah; Afifa Sellami Ben Hamida; Jalel Gargouri; Faiza Fakhfakh; Leila Ammar Keskes is a Medicine article available to read on EtoBox.
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## Background There is clinical evidence to show that sperm DNA damage could be a marker of sperm quality and extensive data exist on the relationship between DNA damage and male fertility status. Detecting such damage in sperm could provide new elements besides semen parameters in diagnosing male infertility. We aimed to assess sperm DNA fragmentation and oxidation and to study the association between these two markers, routine semen parameters and malondialdehyde formation. ## Methods Semen samples from 55 men attending the Histology-Embryology Laboratory of Sfax Faculty of Medicine, Tunisia, for semen investigations were analysed for sperm DNA fragmentation and oxidation using flow cytometry. The Sperm was also assessed spectrophotometrically for malondialdehyde formation. ## Results Within the studied group, 21 patients were nonasthenozoospermic (sperm motility ≥ 50%) and 34 patients were considered asthenozoospermic (sperm motility < 50%). A positive correlation was found between sperm DNA fragmentation and oxidation (p = 0.01; r = 0.33). We also found a negative correlation between sperm DNA fragmentation and some sperm parameters: total motility (p = 0.001; r = -0.43), rapid
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- Author
- Nassira Zribi; Nozha Feki Chakroun; Henda Elleuch; Fatma Ben Abdallah; Afifa Sellami Ben Hamida; Jalel Gargouri; Faiza Fakhfakh; Leila Ammar Keskes
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1477-7827)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)