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Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling by Kuilong Wang; Wei Huang; Xianan Sang; Xin Wu; Qiyuan Shan; Dongxin Tang; Xiaofen Xu; Gang Cao is a Medicine article available to read on EtoBox.
What is Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling about?
## Background: Atractylenolide i (atl-1) is a natural herbal compound used in traditional chinese medicine that has exhibited anti-cancer properties. the anti-tumorigenic activity of atl-1 against colorectal cancer (crc) and the underlying signaling pathways involved in its mechanisms are examined here. ## Hypothesis: Atl-1 exerts therapeutic effect against crc by disrupting glucose metabolism and cancer stem cell maintenance via akt/mtor pathway regulation. ## Study design: In vitro studies were performed in colo205 and hct116 crc cell lines and in vivo studies were conducted in a mouse xenograft model of crc tumor. ## Methods: Crc cells were treated with atl-1 at various concentrations, with or without inhibitors of akt or mtor. cell proliferation, apoptosis, invasion, stemness maintenance, glucose metabolism, and akt/mtor signaling were evaluated. crc tumor-xenografted mice were treated with an akt inhibitor and/or atl-1, and glucose metabolism and stemness maintenance were examined in tumor tissues. ## Results: Atl-1 significantly inhibited the invasion of crc cells by inducing their apoptosis, possibly via the excessive production of reactive oxygen species. glucose metabolism
Who reads Atractylenolide I inhibits colorectal cancer cell proliferation by affecting metabolism and stemness via AKT/mTOR signaling?
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- Author
- Kuilong Wang; Wei Huang; Xianan Sang; Xin Wu; Qiyuan Shan; Dongxin Tang; Xiaofen Xu; Gang Cao
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0944-7113)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Life Sciences)