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The gut virome in Irritable Bowel Syndrome differs from that of controls by S. Coughlan; A. Das; E. O’Herlihy; F. Shanahan; P.W. O’Toole; I.B. Jeffery is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## ABSTRACT Irritable Bowel Syndrome (IBS), the most common gastrointestinal disorder, is diagnosed solely on symptoms. Potentially diagnostic alterations in the bacterial component of the gut microbiome (the bacteriome) are associated with IBS, but despite the known role of the virome (particularly bacteriophages), in shaping the gut bacteriome, few studies have investigated the virome in IBS. We performed metagenomic sequencing of fecal Virus-Like Particles (VLPs) from 55 patients with IBS and 51 control individuals. We detected significantly lower alpha diversity of viral clusters comprising both known and novel viruses (viral ‘dark matter’) in IBS and a significant difference in beta diversity compared to controls, but not between IBS symptom subtypes. The three most abundant bacteriophage clusters belonged to the __Siphoviridae, Myoviridae__, and __Podoviridae__ families (Order __Caudovirales__). A core virome (defined as a cluster present in at least 50% of samples) of 5 and 12 viral clusters was identified in IBS and control subjects, respectively. We also identified a subset of viral clusters that showed differential abundance between IBS and controls. The virome did not co

Who reads The gut virome in Irritable Bowel Syndrome differs from that of controls?

Author

S. Coughlan; A. Das; E. O’Herlihy; F. Shanahan; P.W. O’Toole; I.B. Jeffery

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)