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BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer by Sann Sanda Khin; Riko Kitazawa; Ne Win; Than Than Aye; Kiyoshi Mori; Takeshi Kondo; Sohei Kitazawa is a Medicine article available to read on EtoBox.

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## Abstract The bone morphogenetic protein (BMP) and activin membrane‐bound inhibitor (__BAMBI__) is a transmembrane __TGFRI__/__BMPRI‐__related pseudoreceptor, antagonizes transforming growth factor (TGF)‐β/BMP signaling by inhibiting the formation of functional authentic receptor complexes (__TGFRI__/__BMPRI__ and __TGFRII__/__BMPRII__). On the assumption that __BAMBI__ gene expression is epigenetically altered during human bladder cancer progression, we screened the expression of __BAMBI__ protein by immunohistochemistry and the methylation status of the __BAMBI__ promoter. In the normal or reactive urothelium, __BAMBI__ expression was mostly overlapped with that of __BMPRI__, and a similar colocalization pattern was noted in low‐grade papillary cancers. In high‐grade and invasive cancers, however, mainly two reciprocal immunohistochemical expression patterns were observed: __BAMBI__‐low/__BMPRI__‐high, and __BAMBI__‐high/__BMPRI__‐low, indicating that __BAMBI__ expression is controlled such that it does not interfere with the responsiveness of high‐grade cancer cells to TGF‐β/BMP signaling. Moreover, methylation of the __BAMBI__ gene correlated significantly with negative __BAM

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Author

Sann Sanda Khin; Riko Kitazawa; Ne Win; Than Than Aye; Kiyoshi Mori; Takeshi Kondo; Sohei Kitazawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2009

Language

EN

Field

Medicine (Health Sciences)