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The Efficacy and Safety of Vibrating Capsules for Functional Constipation: a Systematic Review and Meta-analysis of Randomized Controlled Trials by Abdallah Saeed; Mohamed T. Abuelazm; Mohamed Abdelnabi; Mariam Elewidi; Asmaa Khaled; Amr Elzahaby; Amr Mousa; Basel Abdelazeem is a Medicine article available to read on EtoBox.
What is The Efficacy and Safety of Vibrating Capsules for Functional Constipation: a Systematic Review and Meta-analysis of Randomized Controlled Trials about?
Objective: Chronic constipation is a challenging functional gastrointestinal disorder that remains a global burden. Pharmacologic therapy, including laxatives and dietary fibers, are suggested as lines of treatment. Recent trials introduced an orally ingested vibrating capsule (VC) as an eligible option for chronic constipation management. Methods: We conducted a literature search in English on electronic databases CENTRAL, PubMed, EMBASE, Scopus, and WOS until February 27th, 2023. RevMan was used to perform the meta-analysis. The results were reported as risk ratios (RRs), mean differences (MDs), and 95% confidence intervals (CIs). The study protocol was registered in PROSPERO with ID: (CRD42023409422). Results: Three RCTs with a total of 601 patients were included in our analysis. There was no difference between the VC and placebo in responder rate (RR: 1.37 with 95% CI [0.82, 2.28], p 1⁄4 .22), CSBM change from baseline (MD: 0.21 with 95% CI [À0.26, 0.69], p 1⁄4 .38), SBM change from baseline (MD: 0.14 with 95% CI [À0.22, 0.49], p 1⁄4 .46), and the incidence of any adverse event (RR: 1.45 with a 95% CI of [0.79, 2.63], p 1⁄4 .23). However, VC was associated with increased vibrat
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- Author
- Abdallah Saeed; Mohamed T. Abuelazm; Mohamed Abdelnabi; Mariam Elewidi; Asmaa Khaled; Amr Elzahaby; Amr Mousa; Basel Abdelazeem
- Publisher
- Informa UK Limited
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)