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In Vitro Testing and the Carcinogenic Potential of Several Nitrosated Indole Compounds by Henrika G. M. Tiedink; Laura H. J. De Haan; Wim M. F. Jongen; Jan H. Koeman is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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4-chloro-methoxyindole is a naturally occurring compound in Vicia faba which can easily react with nitrite to form a N-nitroso compound. In this in vitro study, the potential genotoxic effects of nitrosated 4-chloro-6-methoxyindole and its structural analogue 4-chloroindole were evaluated for the first time by using both Salmonella and Chinese hamster V79 cells. Additionally, the inhibition of gap junctional intercellular communication in V79 cells by these compounds was determined; this is a validated parameter for tumor-promoting activity. Most assays were also performed with nitrosated indole-3-acetonitrile, a naturally occurring compound in brassicas. Both nitrosated chloroindoles were highly mutagenic to Salmonella typhimurium TA100 without the need of exogenous metabolic activation and were potent inducers of Sister Chromatid Exchanges. Nitrosated indole-3-acetonitrile generated the same effects, although at much higher concentrations. Equivocal results were obtained for the nitrosated chloroindoles in a forward mutation assay using the hypoxanthine guaninephosphoribosyltransferase locus. All nitrosated indole compounds significantly inhibited gap junctional intercellular com

Who reads In Vitro Testing and the Carcinogenic Potential of Several Nitrosated Indole Compounds?

Author

Henrika G. M. Tiedink; Laura H. J. De Haan; Wim M. F. Jongen; Jan H. Koeman

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0742-2091)

Published

1991

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)