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Topical Diclofenac in Hyaluronan Gel for the Treatment of Solar Keratoses by Kurt Gebauer; Pam Brown; George Varigos is a Medicine article available to read on EtoBox.

What is Topical Diclofenac in Hyaluronan Gel for the Treatment of Solar Keratoses about?

## SUMMARY This randomized, double‐blind, placebo‐controlled study assessed the efficacy and safety of a topical gel containing 3% diclofenac in 2.5% hyaluronan in 150 patients with solar keratoses (SK). The active treatment was compared with the vehicle only, hyaluronan gel, as placebo over a 12‐week period. Patients in both groups applied the active treatment or placebo to a targeted area of skin (0.25 g b.d.). At 12 weeks the mean lesion‐count reduction in the targeted area was not significantly different between treatments. However, at post‐termination follow up (16 weeks), there was a highly significant decrease in the number of lesions, 6.2 ± 7.5 standard deviations (SD) (56.1% reduction) in the active treatment group compared with 2.4 ± 4.3 SD (23.6% reduction) in the placebo group (__P__ 50% lesion reduction) were also significantly different (__P__ < 0.01) between treatments at 16 weeks. In conclusion, topical 3% diclofenac in 2.5% hyaluronan gel was effective and well tolerated in this study, suggesting a role for this therapy in the treatment of SK.

Who reads Topical Diclofenac in Hyaluronan Gel for the Treatment of Solar Keratoses?

Author

Kurt Gebauer; Pam Brown; George Varigos

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0004-8380)

Published

2003

Language

EN

Field

Medicine (Health Sciences)