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Synthesis, Biological Evaluation and Quantitative Structure-activities Relationship of Flavonoids as Vasorelaxant Agents by Xiaowu Dong; Tao Liu; Jingying Yan; Peng Wu; Jing Chen; Yongzhou Hu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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A series of flavonoid derivatives were designed, synthesized. Their vasorelaxant activities were evaluated experimentally against rat aorta rings pretreated with phenylephrine (PE). Among them, 6-hydroxy-8allyl-4 0 -chloro-flavanone 8q exhibited the highest vasodilatory activity (EC 50 = 4.6 lM, E max = 95.1%). The 3D-QSAR analysis was carried out by comparative molecular field analysis (CoMFA) method, and a statistically reliable model with good predictive power (r 2 = 0.872 and q 2 cv = 0.496) was established. The contour plots of CoMFA model provide a good insight into the structure-activity relationships of these compounds and may be used to design more potent flavonoids derivatives as vasorelaxant agents.

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Author

Xiaowu Dong; Tao Liu; Jingying Yan; Peng Wu; Jing Chen; Yongzhou Hu

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2009

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)