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Can I read De Novo Synthesis of Orthogonally-Protected C2-Fluoro Digitoxoses and Cymaroses: Development and Application for the Synthesis of Fluorinated Digoxin on EtoBox?
De Novo Synthesis of Orthogonally-Protected C2-Fluoro Digitoxoses and Cymaroses: Development and Application for the Synthesis of Fluorinated Digoxin by Ming Zhang; Hong-Wei Chen; Qing-Quan Liu; Feng-Teng Gao; Yi-Xian Li; Xiang-Guo Hu; Chu-Yi Yu is a Chemistry article available to read on EtoBox.
What is De Novo Synthesis of Orthogonally-Protected C2-Fluoro Digitoxoses and Cymaroses: Development and Application for the Synthesis of Fluorinated Digoxin about?
Inspired by Roush's pioneering work on rare sugars, we have developed a scalable, stereoselective, de novo synthesis of orthogonally protected C2-fluoro digitoxose and cymarose, utilizing Sharpless kinetic resolution and organocatalytic fluorination as key steps. The utility of this strategy is demonstrated by the synthesis of a fluorinated analogue of digoxin, which indicates the fluorine on the sugar ring may have a significant impact on biological activity.
Who reads De Novo Synthesis of Orthogonally-Protected C2-Fluoro Digitoxoses and Cymaroses: Development and Application for the Synthesis of Fluorinated Digoxin?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ming Zhang; Hong-Wei Chen; Qing-Quan Liu; Feng-Teng Gao; Yi-Xian Li; Xiang-Guo Hu; Chu-Yi Yu
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)