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MicroRNAs as Biomarkers of Pain Intensity in Patients With Chronic Fatigue Syndrome by Hadeel A. Al‐Rawaf; Ahmad H. Alghadir; Sami A. Gabr is a Medicine article available to read on EtoBox.

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## Abstract ## Background Numerous experimental models have shown that microRNAs (miRNAs)play an important role in regulating pain processing in clinical pain disorders. In this study, we evaluated a set of miRNAs as diagnostic biomarkers of pain intensity in adolescents with chronic fatigue syndrome (CFS). We then correlated the expression of these miRNAs with the levels of inflammatory markers and pain‐related comorbidities in adolescents with CFS and healthy controls (HCs). ## Methods A total of 150 adolescents, 12 to 18 years of age, participated in this study between April 2016 and April 2017. The participants were classified into 2 groups: adolescents with CFS (__n__ = 100) and HCs (__n__ = 50). Reverse‐transcription polymerase chain reaction was used to evaluate the expression of miR‐558, miR‐146a, miR‐150, miR‐124, and miR‐143. Immunoassay analysis was used to assess the levels of immune inflammatory markers interleukin‐6 (IL‐6), tumor necrosis factor‐α (TNF‐α), and cyclooxygenase‐2 (COX‐2). ## Results Adolescents with CFS showed significantly higher pain thresholds than comparable nonfatigued HCs. Ability to enjoy life and relations with others were the parameters least in

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Author

Hadeel A. Al‐Rawaf; Ahmad H. Alghadir; Sami A. Gabr

Publisher

Wiley

Published

2019

Language

EN

Field

Medicine (Health Sciences)