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Can I read Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies on EtoBox?
Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies by Zachary H. Houston; Jens Bunt; Kok-Siong Chen; Simon Puttick; Christopher B. Howard; Nicholas L. Fletcher; Adrian V. Fuchs; Jiwei Cui; Yi Ju; Gary Cowin; Xin Song; Andrew W. Boyd; Stephen M. Mahler; Linda J. Richards; Frank Caruso; Kristofer J. Thurecht is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies about?
Increasing accumulation and retention of nanomedicines within tumor tissue is a significant challenge, particularly in the case of brain tumors where access to the tumor through the vasculature is restricted by the blood-brain barrier (BBB). This makes the application of nanomedicines in neuro-oncology often considered unfeasible, with efficacy limited to regions of significant disease progression and compromised BBB. However, little is understood about how the evolving tumor-brain physiology during disease progression affects the permeability and retention of designer nanomedicines. We report here the development of a modular nanomedicine platform that, when used in conjunction with a unique model of how tumorigenesis affects BBB integrity, allows investigation of how nanomaterial properties affect uptake and retention in brain tissue. By combining different longitudinal imaging techniques (including positron emission tomography and magnetic resonance imaging), we have evaluated the retention of nanomedicines with predefined physicochemical properties (size and surface functionality) and established a relationship between structure and tissue accumulation as a function of a new pa
Who reads Understanding the Uptake of Nanomedicines at Different Stages of Brain Cancer Using a Modular Nanocarrier Platform and Precision Bispecific Antibodies?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zachary H. Houston; Jens Bunt; Kok-Siong Chen; Simon Puttick; Christopher B. Howard; Nicholas L. Fletcher; Adrian V. Fuchs; Jiwei Cui; Yi Ju; Gary Cowin; Xin Song; Andrew W. Boyd; Stephen M. Mahler; Linda J. Richards; Frank Caruso; Kristofer J. Thurecht
- Publisher
- American Chemical Society; American Chemical Society (ACS) (ISSN 2374-7943)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)