Can I read USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity on EtoBox?

USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity by Xiaochen Wang1 Yijie Su1 Bei Lan1 Xuanyuan Li1 Bodi Zhang1 is a book available to read on EtoBox.

What is USP22 promotes the proliferation and Sorafenib resistance of hepatocellular carcinoma cells via its deubiquitinase activity about?

AbstractUniversity, Tianjin, China.Background: Hepatocellular carcinoma remains one of the most lethal cancers,Email: [email protected] by poor prognosis and low life expectancy. Unfortunately, thereChunze Zhang, Department of Colorectalare very few molecular therapeutic options available for it. Sorafenib is a currentSurgery, Tianjin Union Medical Center,standard first-line treatment for advanced hepatocellular carcinoma, however,Tianjin, China.Email: [email protected] resistance significantly limits its therapeutic efficacy.Yingmei Wang, Department ofMethods: Ubiquitin-specific protease 22 (USP22) expression level and its progGynecology and Obstetrics, Tianjinnostic significance in hepatocellular carcinoma were analyzed using The CancerMedical University General Hospital,Genome Atlas (TCGA) database. A series of cellular experiments related to cellTianjin, China.Email: [email protected] and ferroptosis, and mouse tumor-bearing experiments were perFunding informationformed to investigate the role of USP22 in hepatocellular carcinoma cell growthNational Natural Science Foundation ofand Sorafenib resistance. Flag affinity purification coupled with mass specChina, Grant/Award Numb

Author

Xiaochen Wang1 Yijie Su1 Bei Lan1 Xuanyuan Li1 Bodi Zhang1

Published

2025

Language

EN