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Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis by Joseph F. Mitchel; James J. Barry; Laurine Bow; Tod A. Alberghini; Syed A. Abbas; Raymond G. McKay is a Medicine article available to read on EtoBox.

What is Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis about?

The Channel balloon is a new local drug-delivery catheter that has the dual capability of high-pressure lesion dilation and low-pressure drug infusion. The purpose of this study was to assess the safety and efficacy of this device in the local delivery of urokinase in the porcine model. Three in vivo protocols were performed in 57 anesthetized swine to assess the safety of Channel balloon use in the coronary vasculature, the pharmacokinetics of local urokinase delivery, and the ability of the catheter to lyse intraluminal thrombus. First, safety studies were performed in 18 coronary vessels in 13 pigs to compare angiographic and histologic changes following use of the Channel balloon with conventional balloon angioplasty. Second, intramural deposition of 123 I-labeled urokinase was measured in 24 coronary arteries in 20 pigs to assess the efficiency and technical determinants of urokinase delivery and the time course of intramural drug retention. Finally, an in vivo thrombus model was used in 24 pigs to compare the thrombolytic capacity of local urokinase delivery with the Channel balloon in comparison with conventional urokinase infusion techniques. All balloon inflations and drug

Who reads Local urokinase delivery with the Channel balloon: Device safety, pharmacokinetics of intracoronary drug delivery, and efficacy of thrombolysis?

Author

Joseph F. Mitchel; James J. Barry; Laurine Bow; Tod A. Alberghini; Syed A. Abbas; Raymond G. McKay

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-6569)

Published

1997

Language

EN

Field

Medicine (Health Sciences)