Can I read Oral Presentations - O04.1 Novel pathway to ceftriaxone resistance in clinical isolates of N. gonorrhoeae via point mutations in the RNA polymerase on EtoBox?

Oral Presentations - O04.1 Novel pathway to ceftriaxone resistance in clinical isolates of N. gonorrhoeae via point mutations in the RNA polymerase by Palace, Samantha; Wang, Yi; Rubin, Daniel; Grad, Yonatan is a scholarly article available to read on EtoBox.

What is Oral Presentations - O04.1 Novel pathway to ceftriaxone resistance in clinical isolates of N. gonorrhoeae via point mutations in the RNA polymerase about?

cases had at least one traceable contact with confirmed attendance, and 122 had contacts testing positive. WGS confirmed links between traceable contacts in 82 cases. Reasons for unconfirmed links include contacts testing elsewhere and testing NAAT positive, culture negative. Untraceable contacts were reported in 157 cases; WGS provided possible links in 83, with confirmation in only six, given inherent information unavailability. Cases were grouped into 123 clusters, with eight containing >10 patients. Examination of clusters highlighted gaps in partner finding, including clusters containing heterosexual females with identical strains but no male; heterosexual males with identical strains who reported female sex worker contact; confirmed instances of partner underreporting; and 35 cases with multiple partners but no genetically related case. Conclusion WGS has the potential to improve gonorrhoea PN and control by identifying new links and clusters with significant gaps in partner finding, where PN can be enhanced. Its utility will improve with larger databases. Disclosure No significant relationships.

Author

Palace, Samantha; Wang, Yi; Rubin, Daniel; Grad, Yonatan

Publisher

BMJ Publishing Group Ltd

Published

2019

Language

EN