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BRAFV600E Inhibitor Resistance in Gliomas by István Portörő is a document available to read on EtoBox.
What is BRAFV600E Inhibitor Resistance in Gliomas about?
1) The document describes research on acquired resistance to BRAF inhibition in BRAFV600E mutant gliomas. 2) The researchers found that BRAF inhibitor resistant glioma cells upregulate pro-survival pathways like Wnt and increase receptor tyrosine kinase activity including EGFR and Axl, promoting resistance. 3) Inhibition of EGFR and Axl, either concurrently with BRAF inhibitors or after adaptation, increased tumor cell death and inhibited tumor cell growth, suggesting combination therapies may help overc
- Author
- István Portörő
- Language
- EN