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The Effects of Chain Length on the Secondary Structure of Oligoadenylates by Paulus A. Kroon; George P. Kreishman; James H. Nelson; Sunney I. Chan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The oligoadenylates (Ap)~2–4~A have been studied by proton magnetic resonance (pmr) spectroscopy. All the exterior base protons and a number of the interior base proton resonance have been assigned. The results of this work showed that the adenine bases in these oligoadenylates are intramolecularly stacked at 20°C with their bases oriented preferentially in the __anti__ conformation about their respective glycosidic bonds. The oligomers were found to associate extensively even at concentrations of 0.02 __M__, primarily via “end‐to‐end” stacking. With increasing temperature, the oligomer bases destack, but it is argued that this unfolding process cannot be described in terms of a two‐state stacked versus unstacked model. Instead, the temperature dependences of the base proton chemical shifts support a base‐oscillation model. The relationship between this model and the two‐state model is discussed. Finally, on the basis of the chain‐length dependence of the proton chemical shifts of the various adenine bases, it was concluded that subtle variations in the secondary structure of these oligomers exist with increasing chain length. Evidence is presented to show that the effe

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Author

Paulus A. Kroon; George P. Kreishman; James H. Nelson; Sunney I. Chan

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1974

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)