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Assessment of hormone-like activities in Ginkgo biloba , Elettaria cardamomum and Plantago ovata extracts using in vitro receptor-specific bioassays by Macarena Real; José-Manuel Molina-Molina; Jesús Jimenez; Horacio R. Diéguez; Mariana F. Fernández; Nicolás Olea is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Assessment of hormone-like activities in Ginkgo biloba , Elettaria cardamomum and Plantago ovata extracts using in vitro receptor-specific bioassays about?
Medicinal plants are widely used for the treatment of diseases and for the development of new drugs. This study was designed to determine the presence of hormone-like activities dependent on the activation of human estrogen receptor alpha (hERa) and/or androgen receptor (hAR) in methanol extracts prepared from three medicinal plants historically and currently used for therapeutic purposes: Ginkgo biloba leaves (GBL), Elettaria cardamomum seeds (ECS) and Plantago ovata seeds (POS). After a solid-liquid extraction (SLE) step, their effects on hERa function were assessed in MCF-7 breast cancer cells using the E-Screen bioassay, and their ability to induce hAR-mediated reporter gene expression was evaluated using the androgen-sensitive stable prostatic PALM cell line. Unlike POS extracts, GBL and ECS extracts showed estrogenic (0.07 and 0.20 nM E2Eq mg(-1), respectively) and anti-estrogenic (0.01 and 0.02 μM ICI182780Eq mg(-1), respectively) activities. ECS extracts evidenced androgenic activity (0.30 nM R1881Eq mg(-1)) and POS extracts anti-androgenic activity (22.30 μM ProcEq mg(-1)). According to these findings, these plant extracts may interfere with the endocrine system via one or
Who reads Assessment of hormone-like activities in Ginkgo biloba , Elettaria cardamomum and Plantago ovata extracts using in vitro receptor-specific bioassays?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Macarena Real; José-Manuel Molina-Molina; Jesús Jimenez; Horacio R. Diéguez; Mariana F. Fernández; Nicolás Olea
- Publisher
- Informa UK Limited
- Published
- 2015
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)