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## 11. "C-labelling of heteroaromatic compounds Corresponding to indications in the literature [4,5] fhermal rearrangemenf is proved to be a useful tool to prepare ["Clpyridine and ["Clpyridine-derivatives. The essential of this method to prepare ["Clpyridine is the preparation of an "C-labelled precursor containing the C,Nstructure and its thermal conversion, In initial nonradioactive pyrolysis experiments N-methylpyrrole, N-methyl-pyrrolidine, N-methyl-3-hydroxy-pyrrolidine, butyl-methylamine and 4-hydroxy-butyl-methylamine were tested in order to select the most suitable candidate. N-methyl-pyrrole, giving 79% pyridine, was found to be most usehl. In case of the other amines the portion of pyridine was in the range between 35 to 50 %. 2. 3. 4. .
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It is typically read by researchers, students, and practitioners in Medicine.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Life Sciences)