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phenotypic feature of IPSID. 1 However, IPSID is extremely rare outside the Middle East and North Africa. In most cases, MZL is diagnosed without the support of specific diagnostic biomarkers. 2 Henry et al. also refer to cases diagnosed in restricted geographic areas. The possible link between HMS and splenic MZL was suggested more than 20 years ago by Bates and Bedu-Addo. 3 On the one hand, as they also reported, in most cases, patients with malaria-associated splenomegaly, unlike those with splenic MZL, usually do not have clonal rearrangements of their immunoglobulin genes. 4 On the other hand, plasmodium-infected patients with splenic lymphomas may have a transient reduction in splenic size, but no sustained regression is obtained after antimalarial treatment. 3 Early data supporting an etiopathogenic link between chronic malaria and splenic lymphoma were generally considered to be preliminary and not fully convincing. Malaria parasites have only recently been reported to be present in the spleens of asymptomatic persons who are naturally infected with plasmodia species (either P. falciparum or P. vivax). 5 Although this finding indicates that the potential role of malaria in

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Publisher

Massachusetts Medical Society

Published

2022

Language

EN

Field

Medicine (Health Sciences)