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Mechanisms determining the amelioration of rheumatoid arthritis in pregnancy: A systematic review by Charles Raine; Keziah Austin; Ian Giles is a Medicine article available to read on EtoBox.
What is Mechanisms determining the amelioration of rheumatoid arthritis in pregnancy: A systematic review about?
## Background: The phenomenon of pregnancy-induced remission of rheumatoid arthritis (ra) was first reported by philip hench in 1938. despite extensive efforts, the underlying scientific basis has remained elusive. a number of different potential mechanisms have been investigated. we have undertaken a systematic review of the available peer-reviewed articles involving pregnant patients with ra in order to establish the depth of current scientific understanding of this important topic. ## Methods: This review was conducted according to guidelines of preferred reporting items for systematic reviews and meta-analyses. studies were identified by a thorough search of multiple databases including medline, pubmed and embase. search terms used were different combinations of the keywords: rheumatoid arthritis, inflammatory arthritis, pregnancy, mechanisms, disease activity, relapse and remission. non-english language articles and studies that were not directly relevant were excluded. two independent reviewers (cr and ka) screened the retrieved articles by reading the title and abstract to identify studies that addressed potential mechanisms determining ra activity in pregnancy. articles wer
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- Author
- Charles Raine; Keziah Austin; Ian Giles
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)